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Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes

The spliceosome is a highly complex, dynamic ribonucleoprotein molecular machine that undergoes numerous structural and compositional rearrangements that lead to the formation of its active site. Recent advances in cyroelectron microscopy (cryo-EM) have provided a plethora of near-atomic structural...

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Detalhes bibliográficos
Publicado no:Cold Spring Harb Perspect Biol
Main Authors: Kastner, Berthold, Will, Cindy L., Stark, Holger, Lührmann, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824238/
https://ncbi.nlm.nih.gov/pubmed/30765414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a032417
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