Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, preventing formatio...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Pawellek, Andrea, Ryder, Ursula, Tammsalu, Triin, King, Lewis J, Kreinin, Helmi, Ly, Tony, Hay, Ronald T, Hartley, Richard C, Lamond, Angus I
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2017
Предметы:
Biochemistry and Chemical Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5619949/
https://ncbi.nlm.nih.gov/pubmed/28884683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27402
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы