Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, preventing formatio...

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Bibliographic Details
Published in:eLife
Main Authors: Pawellek, Andrea, Ryder, Ursula, Tammsalu, Triin, King, Lewis J, Kreinin, Helmi, Ly, Tony, Hay, Ronald T, Hartley, Richard C, Lamond, Angus I
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Biochemistry and Chemical Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5619949/
https://ncbi.nlm.nih.gov/pubmed/28884683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27402
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