Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, preventing formatio...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Pawellek, Andrea, Ryder, Ursula, Tammsalu, Triin, King, Lewis J, Kreinin, Helmi, Ly, Tony, Hay, Ronald T, Hartley, Richard C, Lamond, Angus I
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2017
Onderwerpen:
Biochemistry and Chemical Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5619949/
https://ncbi.nlm.nih.gov/pubmed/28884683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27402
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