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Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP
We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, preventing formatio...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5619949/ https://ncbi.nlm.nih.gov/pubmed/28884683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27402 |
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