Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, preventing formatio...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Pawellek, Andrea, Ryder, Ursula, Tammsalu, Triin, King, Lewis J, Kreinin, Helmi, Ly, Tony, Hay, Ronald T, Hartley, Richard C, Lamond, Angus I
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Biochemistry and Chemical Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5619949/
https://ncbi.nlm.nih.gov/pubmed/28884683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27402
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