SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation

Reprogramming of cellular metabolism towards de novo serine production fuels the growth of cancer cells, providing essential precursors such as amino acids and nucleotides and controlling the antioxidant and methylation capacities of the cell. The enzyme serine hydroxymethyltransferase (SHMT) has a...

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Vydáno v:Cell Death Dis
Hlavní autoři: Paone, A, Marani, M, Fiascarelli, A, Rinaldo, S, Giardina, G, Contestabile, R, Paiardini, A, Cutruzzolà, F
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260740/
https://ncbi.nlm.nih.gov/pubmed/25412303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.482
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