SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation

Reprogramming of cellular metabolism towards de novo serine production fuels the growth of cancer cells, providing essential precursors such as amino acids and nucleotides and controlling the antioxidant and methylation capacities of the cell. The enzyme serine hydroxymethyltransferase (SHMT) has a...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Paone, A, Marani, M, Fiascarelli, A, Rinaldo, S, Giardina, G, Contestabile, R, Paiardini, A, Cutruzzolà, F
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260740/
https://ncbi.nlm.nih.gov/pubmed/25412303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.482
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker