A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells

Serine hydroxymethyltransferase (SHMT) is a central enzyme in the metabolic reprogramming of cancer cells, providing activated one-carbon units in the serine-glycine one-carbon metabolism. Previous studies demonstrated that the cytoplasmic isoform of SHMT (SHMT1) plays a relevant role in lung cancer...

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Udgivet i:Oncotarget
Main Authors: Marani, Marina, Paone, Alessio, Fiascarelli, Alessio, Macone, Alberto, Gargano, Maurizio, Rinaldo, Serena, Giardina, Giorgio, Pontecorvi, Valentino, Koes, David, McDermott, Lee, Yang, Tianyi, Paiardini, Alessandro, Contestabile, Roberto, Cutruzzolà, Francesca
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826227/
https://ncbi.nlm.nih.gov/pubmed/26717037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6726
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