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SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation
Reprogramming of cellular metabolism towards de novo serine production fuels the growth of cancer cells, providing essential precursors such as amino acids and nucleotides and controlling the antioxidant and methylation capacities of the cell. The enzyme serine hydroxymethyltransferase (SHMT) has a...
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| Опубликовано в: : | Cell Death Dis |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4260740/ https://ncbi.nlm.nih.gov/pubmed/25412303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.482 |
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