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SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation

Reprogramming of cellular metabolism towards de novo serine production fuels the growth of cancer cells, providing essential precursors such as amino acids and nucleotides and controlling the antioxidant and methylation capacities of the cell. The enzyme serine hydroxymethyltransferase (SHMT) has a...

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Библиографические подробности
Опубликовано в: :Cell Death Dis
Главные авторы: Paone, A, Marani, M, Fiascarelli, A, Rinaldo, S, Giardina, G, Contestabile, R, Paiardini, A, Cutruzzolà, F
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260740/
https://ncbi.nlm.nih.gov/pubmed/25412303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.482
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