Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments

Human serine hydroxymethyltransferase (SHMT) regulates the serine-glycine one carbon metabolism and plays a role in cancer metabolic reprogramming. Two SHMT isozymes are acting in the cell: SHMT1 encoding the cytoplasmic isozyme, and SHMT2 encoding the mitochondrial one. Here we present a molecular...

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Veröffentlicht in:Comput Struct Biotechnol J
Hauptverfasser: Monti, Michele, Guiducci, Giulia, Paone, Alessio, Rinaldo, Serena, Giardina, Giorgio, Liberati, Francesca Romana, Cutruzzolá, Francesca, Tartaglia, Gian Gaetano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Research Network of Computational and Structural Biotechnology 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175283/
https://ncbi.nlm.nih.gov/pubmed/34136101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2021.05.019
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