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Screening and In Vitro Testing of Antifolate Inhibitors of Human Cytosolic Serine Hydroxymethyltransferase
Metabolic reprogramming of tumor cells toward serine catabolism is now recognized as a hallmark of cancer. Serine hydroxymethyltransferase (SHMT), the enzyme providing one-carbon units by converting serine and tetrahydrofolate (H(4)PteGlu) to glycine and 5,10-CH(2)-H(4)PteGlu, therefore represents a...
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| Publicado en: | ChemMedChem |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5438088/ https://ncbi.nlm.nih.gov/pubmed/25677305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500028 |
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