Screening and In Vitro Testing of Antifolate Inhibitors of Human Cytosolic Serine Hydroxymethyltransferase

Metabolic reprogramming of tumor cells toward serine catabolism is now recognized as a hallmark of cancer. Serine hydroxymethyltransferase (SHMT), the enzyme providing one-carbon units by converting serine and tetrahydrofolate (H(4)PteGlu) to glycine and 5,10-CH(2)-H(4)PteGlu, therefore represents a...

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Udgivet i:ChemMedChem
Main Authors: Paiardini, Alessandro, Fiascarelli, Alessio, Rinaldo, Serena, Daidone, Frederick, Giardina, Giorgio, Koes, David R., Parroni, Alessia, Montini, Giulia, Marani, Marina, Paone, Alessio, McDermott, Lee A., Contestabile, Roberto, Cutruzzolà, Francesca
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438088/
https://ncbi.nlm.nih.gov/pubmed/25677305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500028
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