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The Role of an Active Site Mg(2+) in HDV Ribozyme Self-Cleavage: Insights from QM/MM Calculations

The hepatitis delta virus (HDV) ribozyme is a catalytic RNA motif embedded in the human pathogenic HDV RNA. It catalyzes self-cleavage of its sugar-phosphate backbone with direct participation of the active site cytosine C75. Biochemical and structural data support a general acid role of C75. Here,...

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Bibliografiske detaljer
Udgivet i:Phys Chem Chem Phys
Main Authors: Mlýnský, Vojtěch, Walter, Nils G., Šponer, Jiří, Otyepka, Michal, Banáš, Pavel
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256098/
https://ncbi.nlm.nih.gov/pubmed/25412464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cp03857f
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