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The Role of an Active Site Mg(2+) in HDV Ribozyme Self-Cleavage: Insights from QM/MM Calculations
The hepatitis delta virus (HDV) ribozyme is a catalytic RNA motif embedded in the human pathogenic HDV RNA. It catalyzes self-cleavage of its sugar-phosphate backbone with direct participation of the active site cytosine C75. Biochemical and structural data support a general acid role of C75. Here,...
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| Published in: | Phys Chem Chem Phys |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4256098/ https://ncbi.nlm.nih.gov/pubmed/25412464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cp03857f |
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