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Wobble Pairs of the HDV Ribozyme Play Specific Roles in Stabilization of Active Site Dynamics

The hepatitis delta virus (HDV) is the only known human pathogen whose genome contains a catalytic RNA motif (ribozyme). The overall architecture of the HDV ribozyme is that of a double-nested pseudoknot, with two GU pairs flanking the active site. Although extensive studies have shown that mutation...

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Vydáno v:Phys Chem Chem Phys
Hlavní autoři: Sripathi, Kamali N., Banáš, Pavel, Reblova, Kamila, Šponer, Jiři, Otyepka, Michal, Walter, Nils G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324322/
https://ncbi.nlm.nih.gov/pubmed/25631765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cp05083e
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