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General Base Catalysis for Cleavage by the Active-Site Cytosine of the Hepatitis Delta Virus Ribozyme: QM/MM Calculations Establish Chemical Feasibility

The hepatitis delta virus (HDV) ribozyme is an RNA motif embedded in human pathogenic HDV RNA. Previous experimental studies have established that the active-site nucleotide C75 is essential for self-cleavage of the ribozyme, although its exact catalytic role in the process remains debated. Structur...

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書誌詳細
主要な著者: Banáš, Pavel, Rulíšek, Lubomír, Hánošová, Veronika, Svozil, Daniel, Walter, Nils G., Šponer, Jiří, Otyepka, Michal
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566740/
https://ncbi.nlm.nih.gov/pubmed/18686993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp802592z
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