Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

Rho-associated kinase 2 (ROCK2) regulates the secretion of proinflammatory cytokines and the development of autoimmunity in mice. Data from a phase 1 clinical trial demonstrate that oral administration of KD025, a selective ROCK2 inhibitor, to healthy human subjects down-regulates the ability of T c...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zanin-Zhorov, Alexandra, Weiss, Jonathan M., Nyuydzefe, Melanie S., Chen, Wei, Scher, Jose U., Mo, Rigen, Depoil, David, Rao, Nishta, Liu, Ben, Wei, Jianlu, Lucas, Sarah, Koslow, Matthew, Roche, Maria, Schueller, Olivier, Weiss, Sara, Poyurovsky, Masha V., Tonra, James, Hippen, Keli L., Dustin, Michael L., Blazar, Bruce R., Liu, Chuan-ju, Waksal, Samuel D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250132/
https://ncbi.nlm.nih.gov/pubmed/25385601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414189111
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