Isoform-specific targeting of ROCK proteins in immune cells

von Zanin-Zhorov, Alexandra, Flynn, Ryan, Waksal, Samuel D., Blazar, Bruce R.
Veröffentlicht in Small GTPases (2016)

ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells

von Chen, Wei, Nyuydzefe, Melanie S., Weiss, Jonathan M., Zhang, Jingya, Waksal, Samuel D., Zanin-Zhorov, Alexandra
Veröffentlicht in Sci Rep (2018)

ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings

von Weiss, Jonathan M., Chen, Wei, Nyuydzefe, Melanie S., Trzeciak, Alissa, Flynn, Ryan, Tonra, James R., Marusic, Suzana, Blazar, Bruce R., Waksal, Samuel D., Zanin-Zhorov, Alexandra
Veröffentlicht in Sci Signal (2016)

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

von Zanin-Zhorov, Alexandra, Weiss, Jonathan M., Nyuydzefe, Melanie S., Chen, Wei, Scher, Jose U., Mo, Rigen, Depoil, David, Rao, Nishta, Liu, Ben, Wei, Jianlu, Lucas, Sarah, Koslow, Matthew, Roche, Maria, Schueller, Olivier, Weiss, Sara, Poyurovsky, Masha V., Tonra, James, Hippen, Keli L., Dustin, Michael L., Blazar, Bruce R., Liu, Chuan-ju, Waksal, Samuel D.
Veröffentlicht in Proc Natl Acad Sci U S A (2014)

Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10

von Zanin-Zhorov, Alexandra, Weiss, Jonathan M., Trzeciak, Alissa, Chen, Wei, Zhang, Jingya, Nyuydzefe, Melanie S., Arencibia, Carmen, Polimera, Seetharam, Schueller, Olivier, Fuentes-Duculan, Judilyn, Bonifacio, Kathleen M., Kunjravia, Norma, Cueto, Inna, Soung, Jennifer, Fleischmann, Roy M., Kivitz, Alan, Lebwohl, Mark, Nunez, Margarita, Woodson, Johnnie, Smith, Shondra L., West, Robert F., Berger, Mark, Krueger, James G., Ryan, John L., Waksal, Samuel D.
Veröffentlicht in J Immunol (2017)

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

von Flynn, Ryan, Paz, Katelyn, Du, Jing, Reichenbach, Dawn K., Taylor, Patricia A., Panoskaltsis-Mortari, Angela, Vulic, Ante, Luznik, Leo, MacDonald, Kelli K. P., Hill, Geoffrey R., Nyuydzefe, Melanie S., Weiss, Jonathan M., Chen, Wei, Trzeciak, Alissa, Serody, Jon S., Aguilar, Ethan G., Murphy, William J., Maillard, Ivan, Munn, David, Koreth, John, Cutler, Corey S., Antin, Joseph H., Ritz, Jerome, Waksal, Samuel D., Zanin-Zhorov, Alexandra, Blazar, Bruce R.
Veröffentlicht in Blood (2016)