Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function

Foxp3(+)CD4(+)CD25(high) regulatory T cell (Treg) suppression of inflammation depends on T-cell receptor-mediated Nuclear Factor of Activated T cells c1 (NFATc1) activation with reduced Akt activity. We investigated the role of the scaffold protein Disc large homolog 1 (Dlgh1) in linking the T-cell...

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Detalhes bibliográficos
Main Authors: Zanin-Zhorov, Alexandra, Lin, Jiqiang, Scher, Jose, Kumari, Sudha, Blair, David, Hippen, Keli L., Blazar, Bruce R., Abramson, Steven B., Lafaille, Juan J., Dustin, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277153/
https://ncbi.nlm.nih.gov/pubmed/22307621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110120109
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