Protein kinase C-θ mediates negative feedback on regulatory T cell function

T cell receptor (TCR) dependent regulatory T cell (Treg) activity controls effector T cell (Teff) function and is inhibited by the inflammatory cytokine tumor necrosis factor (TNF)-α. Protein kinase C-θ (PKC-θ) recruitment to the immunological synapse is required for full Teff activation. In contras...

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Detalhes bibliográficos
Main Authors: Zanin-Zhorov, Alexandra, Ding, Yi, Kumari, Sudha, Attur, Mukundan, Hippen, Keli L., Brown, Maryanne, Blazar, Bruce R., Abramson, Steven B., Lafaille, Juan J., Dustin, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905626/
https://ncbi.nlm.nih.gov/pubmed/20339032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1186068
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