Small-Molecule Inhibitors of SETD8 with Cellular Activity

[Image: see text] SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase (PKMT) known to monomethylate lysine 20 of histone H4 in vivo. SETD8’s methyltransferase activity has been implicated in many essential cellular processes including DNA replication, DNA damage response, transcrip...

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Опубликовано в: :ACS Chem Biol
Главные авторы: Blum, Gil, Ibáñez, Glorymar, Rao, Xiangjun, Shum, David, Radu, Constantin, Djaballah, Hakim, Rice, Judd C., Luo, Minkui
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245162/
https://ncbi.nlm.nih.gov/pubmed/25137013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500515r
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