Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen

AIMS: Tamoxifen is considered a pro-drug of its active metabolite endoxifen. The major metabolic enzymes involved in endoxifen formation are CYP2D6 and CYP3A. There is considerable evidence that variability in activity of these enzymes influences endoxifen exposure and thereby may influence the clin...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Br J Clin Pharmacol
Autores principales: ter Heine, Rob, Binkhorst, Lisette, de Graan, Anne Joy M, de Bruijn, Peter, Beijnen, Jos H, Mathijssen, Ron H J, Huitema, Alwin D R
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
Materias:
Drug Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243908/
https://ncbi.nlm.nih.gov/pubmed/24697814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12388
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares