Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen

AIMS: Tamoxifen is considered a pro-drug of its active metabolite endoxifen. The major metabolic enzymes involved in endoxifen formation are CYP2D6 and CYP3A. There is considerable evidence that variability in activity of these enzymes influences endoxifen exposure and thereby may influence the clin...

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Библиографические подробности
Опубликовано в: :Br J Clin Pharmacol
Главные авторы: ter Heine, Rob, Binkhorst, Lisette, de Graan, Anne Joy M, de Bruijn, Peter, Beijnen, Jos H, Mathijssen, Ron H J, Huitema, Alwin D R
Формат: Artigo
Язык:Inglês
Опубликовано: BlackWell Publishing Ltd 2014
Предметы:
Drug Interactions
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243908/
https://ncbi.nlm.nih.gov/pubmed/24697814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12388
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