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Augmentation of Endoxifen Exposure in Tamoxifen-Treated Women Following SSRI Switch
BACKGROUND AND OBJECTIVE: The anti-oestrogen tamoxifen requires metabolic activation to endoxifen by cytochrome P450 (CYP) enzymes, predominantly CYP2D6. Potent CYP2D6-inhibiting antidepressants can seriously disrupt tamoxifen metabolism, probably influencing the efficacy of tamoxifen. For this reas...
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| Publicado no: | Clin Pharmacokinet |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4756062/ https://ncbi.nlm.nih.gov/pubmed/26446141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0315-x |
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