Augmentation of Endoxifen Exposure in Tamoxifen-Treated Women Following SSRI Switch

BACKGROUND AND OBJECTIVE: The anti-oestrogen tamoxifen requires metabolic activation to endoxifen by cytochrome P450 (CYP) enzymes, predominantly CYP2D6. Potent CYP2D6-inhibiting antidepressants can seriously disrupt tamoxifen metabolism, probably influencing the efficacy of tamoxifen. For this reas...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: Binkhorst, Lisette, Bannink, Marjolein, de Bruijn, Peter, Ruit, Jan, Droogendijk, Helga, van Alphen, Robbert J., den Boer, Tilly D., Lam, Mei Ho, Jager, Agnes, van Gelder, Teun, Mathijssen, Ron H. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2015
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756062/
https://ncbi.nlm.nih.gov/pubmed/26446141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0315-x
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