Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen

AIMS: Tamoxifen is considered a pro-drug of its active metabolite endoxifen. The major metabolic enzymes involved in endoxifen formation are CYP2D6 and CYP3A. There is considerable evidence that variability in activity of these enzymes influences endoxifen exposure and thereby may influence the clin...

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Bibliografski detalji
Izdano u:Br J Clin Pharmacol
Glavni autori: ter Heine, Rob, Binkhorst, Lisette, de Graan, Anne Joy M, de Bruijn, Peter, Beijnen, Jos H, Mathijssen, Ron H J, Huitema, Alwin D R
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2014
Teme:
Drug Interactions
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243908/
https://ncbi.nlm.nih.gov/pubmed/24697814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12388
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