Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen

AIMS: Tamoxifen is considered a pro-drug of its active metabolite endoxifen. The major metabolic enzymes involved in endoxifen formation are CYP2D6 and CYP3A. There is considerable evidence that variability in activity of these enzymes influences endoxifen exposure and thereby may influence the clin...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: ter Heine, Rob, Binkhorst, Lisette, de Graan, Anne Joy M, de Bruijn, Peter, Beijnen, Jos H, Mathijssen, Ron H J, Huitema, Alwin D R
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243908/
https://ncbi.nlm.nih.gov/pubmed/24697814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12388
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