Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa

AIMS: Thiotepa is widely used in high-dose chemotherapy. Previous studies have shown relations between exposure and severe organ toxicity. Thiotepa is metabolized by cytochrome P450 and glutathione S-transferase enzymes. Polymorphisms of these enzymes may affect elimination of thiotepa and tepa, its...

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Main Authors: Ekhart, Corine, Doodeman, Valerie D, Rodenhuis, Sjoerd, Smits, Paul H M, Beijnen, Jos H, Huitema, Alwin D R
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2009
Fag:
Pharmacogenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668084/
https://ncbi.nlm.nih.gov/pubmed/19076156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03321.x
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