Circadian variation in tamoxifen pharmacokinetics in mice and breast cancer patients

The anti-estrogen tamoxifen is characterized by a large variability in response, partly due to pharmacokinetic differences. We examined circadian variation in tamoxifen pharmacokinetics in mice and breast cancer patients. Pharmacokinetic analysis was performed in mice, dosed at six different times (...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res Treat
Main Authors: Binkhorst, Lisette, Kloth, Jacqueline S. L., de Wit, Annelieke S., de Bruijn, Peter, Lam, Mei H., Chaves, Ines, Burger, Herman, van Alphen, Robbert J., Hamberg, Paul, van Schaik, Ron H. N., Jager, Agnes, Koch, Birgit C. P., Wiemer, Erik A. C., van Gelder, Teun, van der Horst, Gijsbertus T. J., Mathijssen, Ron H. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
Assuntos:
Clinical Trial
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469299/
https://ncbi.nlm.nih.gov/pubmed/26050156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-015-3452-x
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