Impact of Curcumin (with or without Piperine) on the Pharmacokinetics of Tamoxifen

Tamoxifen is a prodrug that is primarily metabolized into the pharmacologically active metabolite endoxifen and eventually into inactive metabolites. The herb curcumin may increase endoxifen exposure by affecting phase II metabolism. We compared endoxifen and tamoxifen exposure in breast cancer pati...

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Udgivet i:Cancers (Basel)
Main Authors: Hussaarts, Koen G.A.M., Hurkmans, Daan P., Oomen-de Hoop, Esther, van Harten, Leonie J., Berghuis, Stan, van Alphen, Robbert J., Spierings, Leontine E.A., van Rossum-Schornagel, Quirine C., Vastbinder, Mijntje B., van Schaik, Ron H.N., van Gelder, Teun, Jager, Agnes, van Leeuwen, Roelof W.F., Mathijssen, Ron H.J.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468355/
https://ncbi.nlm.nih.gov/pubmed/30909366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11030403
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