Simplified phenotyping of CYP2D6 for tamoxifen treatment using the N-desmethyl-tamoxifen/ endoxifen ratio

INTRODUCTION: CYP2D6 protein activity can be inferred from the ratio of N-desmethyl-tamoxifen (NDMT) to endoxifen (E). CYP2D6 polymorphisms are common and can affect CYP2D6 protein activity and E level. Some retrospective studies indicate that E < 16 nM may relate to worse outcome. MATERIALS AND...

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書誌詳細
出版年:Breast
主要な著者: Lee, Clara Inkyung, Low, Siew Kee, Maldonado, Ricardo, Fox, Peter, Balakrishnar, Bavanthi, Coulter, Sally, de Bruijn, Peter, Koolen, Stijn L.W., Gao, Bo, Lynch, Jodi, Zdenkowski, Nicholas, Hui, Rina, Liddle, Christopher, Mathijssen, Ron H.J., Wilcken, Nicholas, Wong, Mark, Gurney, Howard
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2020
主題:
Original Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653100/
https://ncbi.nlm.nih.gov/pubmed/33161337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.breast.2020.10.008
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