Cyclin C is a haploinsufficient tumor suppressor

Cyclin C was cloned as a growth-promoting G1 cyclin, and was also shown to regulate gene transcription. Here we report that in vivo cyclin C acts as a haploinsufficient tumor suppressor, by controlling Notch1 oncogene levels. Cyclin C activates an “orphan” CDK19 kinase, as well as CDK8 and CDK3. The...

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Detaylı Bibliyografya
Yayımlandı:Nat Cell Biol
Asıl Yazarlar: Li, Na, Fassl, Anne, Chick, Joel, Inuzuka, Hiroyuki, Li, Xiaoyu, Mansour, Marc R., Liu, Lijun, Wang, Haizhen, King, Bryan, Shaik, Shavali, Gutierrez, Alejandro, Ordureau, Alban, Otto, Tobias, Kreslavsky, Taras, Baitsch, Lukas, Bury, Leah, Meyer, Clifford A., Ke, Nan, Mulry, Kristin A., Kluk, Michael J., Roy, Moni, Kim, Sunkyu, Zhang, Xiaowu, Geng, Yan, Zagozdzon, Agnieszka, Jenkinson, Sarah, Gale, Rosemary E., Linch, David C., Zhao, Jean J., Mullighan, Charles G., Harper, J. Wade, Aster, Jon C., Aifantis, Iannis, von Boehmer, Harald, Gygi, Steven P., Wei, Wenyi, Look, A. Thomas, Sicinski, Piotr
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235773/
https://ncbi.nlm.nih.gov/pubmed/25344755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3046
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