Cyclin C is a haploinsufficient tumor suppressor

Cyclin C was cloned as a growth-promoting G1 cyclin, and was also shown to regulate gene transcription. Here we report that in vivo cyclin C acts as a haploinsufficient tumor suppressor, by controlling Notch1 oncogene levels. Cyclin C activates an “orphan” CDK19 kinase, as well as CDK8 and CDK3. The...

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Publicado no:Nat Cell Biol
Main Authors: Li, Na, Fassl, Anne, Chick, Joel, Inuzuka, Hiroyuki, Li, Xiaoyu, Mansour, Marc R., Liu, Lijun, Wang, Haizhen, King, Bryan, Shaik, Shavali, Gutierrez, Alejandro, Ordureau, Alban, Otto, Tobias, Kreslavsky, Taras, Baitsch, Lukas, Bury, Leah, Meyer, Clifford A., Ke, Nan, Mulry, Kristin A., Kluk, Michael J., Roy, Moni, Kim, Sunkyu, Zhang, Xiaowu, Geng, Yan, Zagozdzon, Agnieszka, Jenkinson, Sarah, Gale, Rosemary E., Linch, David C., Zhao, Jean J., Mullighan, Charles G., Harper, J. Wade, Aster, Jon C., Aifantis, Iannis, von Boehmer, Harald, Gygi, Steven P., Wei, Wenyi, Look, A. Thomas, Sicinski, Piotr
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235773/
https://ncbi.nlm.nih.gov/pubmed/25344755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3046
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