Sex steroid blockade enhances thymopoiesis by modulating Notch signaling

Paradoxical to its importance for generating a diverse T cell repertoire, thymic function progressively declines throughout life. This process has been at least partially attributed to the effects of sex steroids, and their removal promotes enhanced thymopoiesis and recovery from immune injury. We s...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Velardi, Enrico, Tsai, Jennifer J., Holland, Amanda M., Wertheimer, Tobias, Yu, Vionnie W.C., Zakrzewski, Johannes L., Tuckett, Andrea Z., Singer, Natalie V., West, Mallory L., Smith, Odette M., Young, Lauren F., Kreines, Fabiana M., Levy, Emily R., Boyd, Richard L., Scadden, David T., Dudakov, Jarrod A., van den Brink, Marcel R.M.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2014
Matèries:
Brief Definitive Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235646/
https://ncbi.nlm.nih.gov/pubmed/25332287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131289
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