Sex steroid blockade enhances thymopoiesis by modulating Notch signaling

Paradoxical to its importance for generating a diverse T cell repertoire, thymic function progressively declines throughout life. This process has been at least partially attributed to the effects of sex steroids, and their removal promotes enhanced thymopoiesis and recovery from immune injury. We s...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Exp Med
Päätekijät: Velardi, Enrico, Tsai, Jennifer J., Holland, Amanda M., Wertheimer, Tobias, Yu, Vionnie W.C., Zakrzewski, Johannes L., Tuckett, Andrea Z., Singer, Natalie V., West, Mallory L., Smith, Odette M., Young, Lauren F., Kreines, Fabiana M., Levy, Emily R., Boyd, Richard L., Scadden, David T., Dudakov, Jarrod A., van den Brink, Marcel R.M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2014
Aiheet:
Brief Definitive Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235646/
https://ncbi.nlm.nih.gov/pubmed/25332287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131289
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