CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

[Image: see text] We have recently identified 1,8-naphthyridin-2(1H)-one-3-carboxamide as a new scaffold very suitable for the development of new CB2 receptor potent and selective ligands. In this paper we describe a number of additional derivatives in which the same central scaffold has been variou...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Lucchesi, Valentina, Hurst, Dow P., Shore, Derek M., Bertini, Simone, Ehrmann, Brandie M., Allarà, Marco, Lawrence, Lyle, Ligresti, Alessia, Minutolo, Filippo, Saccomanni, Giuseppe, Sharir, Haleli, Macchia, Marco, Di Marzo, Vincenzo, Abood, Mary E., Reggio, Patricia H., Manera, Clementina
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234427/
https://ncbi.nlm.nih.gov/pubmed/25272206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500807e
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