Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor

In this work, we explored the molecular framework of the known CB1R allosteric modulator PSNCBAM-1 with the aim to generate new bioactive analogs and to deepen the structure-activity relationships of this type of compounds. In particular, the introduction of a NH group between the pyridine ring and...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Bertini, Simone, Chicca, Andrea, Gado, Francesca, Arena, Chiara, Nieri, Daniela, Digiacomo, Maria, Saccomanni, Giuseppe, Zhao, Pingwei, Abood, Mary E., Macchia, Marco, Ghertsch, Jürg, Manera, Clementina
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794004/
https://ncbi.nlm.nih.gov/pubmed/29079014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.10.015
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