Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist

Preclinical studies highlighted that compounds targeting cannabinoid receptors could be useful for developing novel therapies against neurodegenerative disorders. However, the chronic use of orthosteric agonists alone has several disadvantages, limiting their usefulness as clinically relevant drugs....

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Dades bibliogràfiques
Publicat a:Life (Basel)
Autors principals: Polini, Beatrice, Cervetto, Chiara, Carpi, Sara, Pelassa, Simone, Gado, Francesca, Ferrisi, Rebecca, Bertini, Simone, Nieri, Paola, Marcoli, Manuela, Manera, Clementina
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
Matèries:
Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7763181/
https://ncbi.nlm.nih.gov/pubmed/33302569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/life10120333
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