Structural Optimization of the Diarylurea PSNCBAM-1, an Allosteric Modulator of Cannabinoid Receptor 1

BACKGROUND: Structure–activity relationship studies improve the pharmacological and pharmacokinetic properties of a lead compound such as PSNCBAM-1, an allosteric modulator of the cannabinoid receptor 1. OBJECTIVES: Here, several derivatives of PSNCBAM-1 were synthesized with the aim of reducing the...

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Bibliographic Details
Published in:Curr Ther Res Clin Exp
Main Authors: Dopart, Rachel, Immadi, Sri Sujana, Lu, Dai, Kendall, Debra A.
Format: Artigo
Language:Inglês
Published: Elsevier 2019
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994307/
https://ncbi.nlm.nih.gov/pubmed/32021660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.curtheres.2019.100574
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