Pyrimidinyl Biphenylureas: Identification of New Lead Compounds as Allosteric Modulators of the Cannabinoid Receptor CB(1)

The allosteric modulator 1-(4-chlorophenyl)-3-(3-(6-(pyrrolidin-1-yl)pyridin-2-yl)phenyl)urea (PSNCBAM-1, 2) bound the cannabinoid receptor 1 (CB(1)) and antagonized G protein coupling. This compound demonstrated potent anorectic effects similar to the CB(1) antagonist rimonabant that once was marke...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Med Chem
Prif Awduron: Khurana, Leepakshi, Fu, Bo-Qiao, Duddupudi, Anantha L., Liao, Yu-Hsien, Immadi, Sri Sujana, Kendall, Debra A., Lu, Dai
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724760/
https://ncbi.nlm.nih.gov/pubmed/28059509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01448
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