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Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate β-Arrestin–Dependent Responses
Cannabinoid receptor 1 (CB(1)) is a G-protein–coupled receptor that is abundant in the central nervous system. It binds several compounds in its orthosteric site, including the endocannabinoids, arachidonoyl ethanolamide (anandamide) and 2-arachidonoyl glycerol, and the plant-derived Δ(9)-tetrahydro...
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| Publicado no: | Mol Pharmacol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6277924/ https://ncbi.nlm.nih.gov/pubmed/30322873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112854 |
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