Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate β-Arrestin–Dependent Responses

Cannabinoid receptor 1 (CB(1)) is a G-protein–coupled receptor that is abundant in the central nervous system. It binds several compounds in its orthosteric site, including the endocannabinoids, arachidonoyl ethanolamide (anandamide) and 2-arachidonoyl glycerol, and the plant-derived Δ(9)-tetrahydro...

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Bibliographic Details
Published in:Mol Pharmacol
Main Authors: Jagla, Caitlin A. D., Scott, Caitlin E., Tang, Yaliang, Qiao, Changjiang, Mateo-Semidey, Gabriel E., Yudowski, Guillermo A., Lu, Dai, Kendall, Debra A.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277924/
https://ncbi.nlm.nih.gov/pubmed/30322873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112854
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