Structure Activity Relationships of α(v) Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents

[Image: see text] Antagonism of α(v)β(6) is emerging as a potential treatment of idiopathic pulmonary fibrosis based on strong target validation. Starting from an α(v)β(3) antagonist lead and through simple variation in the nature and position of the aryl substituent, the discovery of compounds with...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Adams, James, Anderson, Edward C., Blackham, Emma E., Chiu, Yin Wa Ryan, Clarke, Thomas, Eccles, Natasha, Gill, Luke A., Haye, Joshua J., Haywood, Harvey T., Hoenig, Christian R., Kausas, Marius, Le, Joelle, Russell, Hannah L., Smedley, Christopher, Tipping, William J., Tongue, Tom, Wood, Charlotte C., Yeung, Jason, Rowedder, James E., Fray, M. Jonathan, McInally, Thomas, Macdonald, Simon J. F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2014
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233353/
https://ncbi.nlm.nih.gov/pubmed/25408832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002079
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