Structure Activity Relationships of α(v) Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents

[Image: see text] Antagonism of α(v)β(6) is emerging as a potential treatment of idiopathic pulmonary fibrosis based on strong target validation. Starting from an α(v)β(3) antagonist lead and through simple variation in the nature and position of the aryl substituent, the discovery of compounds with...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Adams, James, Anderson, Edward C., Blackham, Emma E., Chiu, Yin Wa Ryan, Clarke, Thomas, Eccles, Natasha, Gill, Luke A., Haye, Joshua J., Haywood, Harvey T., Hoenig, Christian R., Kausas, Marius, Le, Joelle, Russell, Hannah L., Smedley, Christopher, Tipping, William J., Tongue, Tom, Wood, Charlotte C., Yeung, Jason, Rowedder, James E., Fray, M. Jonathan, McInally, Thomas, Macdonald, Simon J. F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233353/
https://ncbi.nlm.nih.gov/pubmed/25408832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002079
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