Structure Activity Relationships of α(v) Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents

[Image: see text] Antagonism of α(v)β(6) is emerging as a potential treatment of idiopathic pulmonary fibrosis based on strong target validation. Starting from an α(v)β(3) antagonist lead and through simple variation in the nature and position of the aryl substituent, the discovery of compounds with...

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Publicado en:ACS Med Chem Lett
Autores principales: Adams, James, Anderson, Edward C., Blackham, Emma E., Chiu, Yin Wa Ryan, Clarke, Thomas, Eccles, Natasha, Gill, Luke A., Haye, Joshua J., Haywood, Harvey T., Hoenig, Christian R., Kausas, Marius, Le, Joelle, Russell, Hannah L., Smedley, Christopher, Tipping, William J., Tongue, Tom, Wood, Charlotte C., Yeung, Jason, Rowedder, James E., Fray, M. Jonathan, McInally, Thomas, Macdonald, Simon J. F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233353/
https://ncbi.nlm.nih.gov/pubmed/25408832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002079
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