Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis

Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder characterized by lesions composed of pathological CD207(+) dendritic cells with an inflammatory infiltrate. BRAFV600E remains the only recurrent mutation reported in LCH. In order to evaluate the spectrum of somatic mutations in LC...

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Publicado en:Blood
Autores principales: Chakraborty, Rikhia, Hampton, Oliver A., Shen, Xiaoyun, Simko, Stephen J., Shih, Albert, Abhyankar, Harshal, Lim, Karen Phaik Har, Covington, Kyle R., Trevino, Lisa, Dewal, Ninad, Muzny, Donna M., Doddapaneni, Harshavardhan, Hu, Jianhong, Wang, Linghua, Lupo, Philip J., Hicks, M. John, Bonilla, Diana L., Dwyer, Karen C., Berres, Marie-Luise, Poulikakos, Poulikos I., Merad, Miriam, McClain, Kenneth L., Wheeler, David A., Allen, Carl E., Parsons, D. Williams
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2014
Materias:
Myeloid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224195/
https://ncbi.nlm.nih.gov/pubmed/25202140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-577825
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