BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups

Langerhans cell histiocytosis (LCH) is a clonal disorder with elusive etiology, characterized by the accumulation of CD207(+) dendritic cells (DCs) in inflammatory lesions. Recurrent BRAF-V600E mutations have been reported in LCH. In this study, lesions from 100 patients were genotyped, and 64% carr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Berres, Marie-Luise, Lim, Karen Phaik Har, Peters, Tricia, Price, Jeremy, Takizawa, Hitoshi, Salmon, Hélène, Idoyaga, Juliana, Ruzo, Albert, Lupo, Philip J., Hicks, M. John, Shih, Albert, Simko, Stephen J., Abhyankar, Harshal, Chakraborty, Rikhia, Leboeuf, Marylene, Beltrão, Monique, Lira, Sérgio A., Heym, Kenneth M., Clausen, Björn E., Bigley, Venetia, Collin, Matthew, Manz, Markus G., McClain, Kenneth, Merad, Miriam, Allen, Carl E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978272/
https://ncbi.nlm.nih.gov/pubmed/24638167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130977
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados