Overcoming T-cell exhaustion in LCH: PD-1 blockade and targeted MAPK inhibition are synergistic in a mouse model of LCH

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207(+) dendritic cells (DCs) with persistent MAPK pathway activation. Standard-of-care chemotherapies are inadequate for most patients with multisystem disease, a...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Sengal, Amel, Velazquez, Jessica, Hahne, Meryl, Burke, Thomas M., Abhyankar, Harshal, Reyes, Robert, Olea, Walter, Scull, Brooks, Eckstein, Olive S., Bigenwald, Camille, Bollard, Catherine M., Yu, Wendong, Merad, Miriam, McClain, Kenneth L., Allen, Carl E., Chakraborty, Rikhia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2021
Onderwerpen:
Myeloid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020265/
https://ncbi.nlm.nih.gov/pubmed/33075814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005867
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