Overcoming T-cell exhaustion in LCH: PD-1 blockade and targeted MAPK inhibition are synergistic in a mouse model of LCH

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207(+) dendritic cells (DCs) with persistent MAPK pathway activation. Standard-of-care chemotherapies are inadequate for most patients with multisystem disease, a...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Sengal, Amel, Velazquez, Jessica, Hahne, Meryl, Burke, Thomas M., Abhyankar, Harshal, Reyes, Robert, Olea, Walter, Scull, Brooks, Eckstein, Olive S., Bigenwald, Camille, Bollard, Catherine M., Yu, Wendong, Merad, Miriam, McClain, Kenneth L., Allen, Carl E., Chakraborty, Rikhia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2021
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020265/
https://ncbi.nlm.nih.gov/pubmed/33075814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005867
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