Overcoming T-cell exhaustion in LCH: PD-1 blockade and targeted MAPK inhibition are synergistic in a mouse model of LCH

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207(+) dendritic cells (DCs) with persistent MAPK pathway activation. Standard-of-care chemotherapies are inadequate for most patients with multisystem disease, a...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Sengal, Amel, Velazquez, Jessica, Hahne, Meryl, Burke, Thomas M., Abhyankar, Harshal, Reyes, Robert, Olea, Walter, Scull, Brooks, Eckstein, Olive S., Bigenwald, Camille, Bollard, Catherine M., Yu, Wendong, Merad, Miriam, McClain, Kenneth L., Allen, Carl E., Chakraborty, Rikhia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020265/
https://ncbi.nlm.nih.gov/pubmed/33075814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005867
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