Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is characterized by inflammatory lesions containing pathologic CD207(+) dendritic cells with constitutively activated ERK. Mutually exclusive somatic mutations in MAPK pathway genes have been identified in ∼75% of LCH cases, including recurrent BRAF-V600E and MAP2...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Chakraborty, Rikhia, Burke, Thomas M., Hampton, Oliver A., Zinn, Daniel J., Lim, Karen Phaik Har, Abhyankar, Harshal, Scull, Brooks, Kumar, Vijetha, Kakkar, Nipun, Wheeler, David A., Roy, Angshumoy, Poulikakos, Poulikos I., Merad, Miriam, McClain, Kenneth L., Parsons, D. Williams, Allen, Carl E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2016
Konular:
Myeloid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123197/
https://ncbi.nlm.nih.gov/pubmed/27729324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-733790
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