The NAMPT Promoter Is Regulated by Mechanical Stress, Signal Transducer and Activator of Transcription 5, and Acute Respiratory Distress Syndrome–Associated Genetic Variants

Increased nicotinamide phosphoribosyltransferase (NAMPT) transcription is mechanistically linked to ventilator-induced inflammatory lung injury (VILI), with VILI severity attenuated by reduced NAMPT bioavailability. The molecular mechanisms of NAMPT promoter regulation in response to excessive mecha...

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Bibliografiske detaljer
Udgivet i:Am J Respir Cell Mol Biol
Main Authors: Sun, Xiaoguang, Elangovan, Venkateswaran Ramamoorthi, Mapes, Brandon, Camp, Sara M., Sammani, Saad, Saadat, Laleh, Ceco, Ermelinda, Ma, Shwu-Fan, Flores, Carlos, MacDougall, Matthew S., Quijada, Hector, Liu, Bin, Kempf, Carrie L., Wang, Ting, Chiang, Eddie T., Garcia, Joe G. N.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2014
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224084/
https://ncbi.nlm.nih.gov/pubmed/24821571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0117OC
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