The NAMPT Promoter Is Regulated by Mechanical Stress, Signal Transducer and Activator of Transcription 5, and Acute Respiratory Distress Syndrome–Associated Genetic Variants

Increased nicotinamide phosphoribosyltransferase (NAMPT) transcription is mechanistically linked to ventilator-induced inflammatory lung injury (VILI), with VILI severity attenuated by reduced NAMPT bioavailability. The molecular mechanisms of NAMPT promoter regulation in response to excessive mecha...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Sun, Xiaoguang, Elangovan, Venkateswaran Ramamoorthi, Mapes, Brandon, Camp, Sara M., Sammani, Saad, Saadat, Laleh, Ceco, Ermelinda, Ma, Shwu-Fan, Flores, Carlos, MacDougall, Matthew S., Quijada, Hector, Liu, Bin, Kempf, Carrie L., Wang, Ting, Chiang, Eddie T., Garcia, Joe G. N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224084/
https://ncbi.nlm.nih.gov/pubmed/24821571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0117OC
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