The NAMPT Promoter Is Regulated by Mechanical Stress, Signal Transducer and Activator of Transcription 5, and Acute Respiratory Distress Syndrome–Associated Genetic Variants

Increased nicotinamide phosphoribosyltransferase (NAMPT) transcription is mechanistically linked to ventilator-induced inflammatory lung injury (VILI), with VILI severity attenuated by reduced NAMPT bioavailability. The molecular mechanisms of NAMPT promoter regulation in response to excessive mecha...

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Enregistré dans:
Détails bibliographiques
Publié dans:Am J Respir Cell Mol Biol
Auteurs principaux: Sun, Xiaoguang, Elangovan, Venkateswaran Ramamoorthi, Mapes, Brandon, Camp, Sara M., Sammani, Saad, Saadat, Laleh, Ceco, Ermelinda, Ma, Shwu-Fan, Flores, Carlos, MacDougall, Matthew S., Quijada, Hector, Liu, Bin, Kempf, Carrie L., Wang, Ting, Chiang, Eddie T., Garcia, Joe G. N.
Format: Artigo
Langue:Inglês
Publié: American Thoracic Society 2014
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224084/
https://ncbi.nlm.nih.gov/pubmed/24821571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0117OC
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