Unique Toll-Like Receptor 4 Activation by NAMPT/PBEF Induces NFκB Signaling and Inflammatory Lung Injury

Ventilator-induced inflammatory lung injury (VILI) is mechanistically linked to increased NAMPT transcription and circulating levels of nicotinamide phosphoribosyl-transferase (NAMPT/PBEF). Although VILI severity is attenuated by reduced NAMPT/PBEF bioavailability, the precise contribution of NAMPT/...

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Pubblicato in:Sci Rep
Autori principali: Camp, Sara M., Ceco, Ermelinda, Evenoski, Carrie L., Danilov, Sergei M., Zhou, Tong, Chiang, Eddie T., Moreno-Vinasco, Liliana, Mapes, Brandon, Zhao, Jieling, Gursoy, Gamze, Brown, Mary E., Adyshev, Djanybek M., Siddiqui, Shahid S., Quijada, Hector, Sammani, Saad, Letsiou, Eleftheria, Saadat, Laleh, Yousef, Mohammed, Wang, Ting, Liang, Jie, Garcia, Joe G. N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536637/
https://ncbi.nlm.nih.gov/pubmed/26272519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13135
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