The NAMPT Promoter Is Regulated by Mechanical Stress, Signal Transducer and Activator of Transcription 5, and Acute Respiratory Distress Syndrome–Associated Genetic Variants

Increased nicotinamide phosphoribosyltransferase (NAMPT) transcription is mechanistically linked to ventilator-induced inflammatory lung injury (VILI), with VILI severity attenuated by reduced NAMPT bioavailability. The molecular mechanisms of NAMPT promoter regulation in response to excessive mecha...

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Dades bibliogràfiques
Publicat a:Am J Respir Cell Mol Biol
Autors principals: Sun, Xiaoguang, Elangovan, Venkateswaran Ramamoorthi, Mapes, Brandon, Camp, Sara M., Sammani, Saad, Saadat, Laleh, Ceco, Ermelinda, Ma, Shwu-Fan, Flores, Carlos, MacDougall, Matthew S., Quijada, Hector, Liu, Bin, Kempf, Carrie L., Wang, Ting, Chiang, Eddie T., Garcia, Joe G. N.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2014
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224084/
https://ncbi.nlm.nih.gov/pubmed/24821571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0117OC
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