Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands. However, structural studies have been limited to capsid monomers (CA), and the mechanistic basis for how these ligands inf...

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Bibliografiska uppgifter
Huvudupphovsmän: Price, Amanda J., Jacques, David A., McEwan, William A., Fletcher, Adam J., Essig, Sebastian, Chin, Jason W., Halambage, Upul D., Aiken, Christopher, James, Leo C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214760/
https://ncbi.nlm.nih.gov/pubmed/25356722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004459
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