Compensatory Substitutions in the HIV-1 Capsid Reduce the Fitness Cost Associated with Resistance to a Capsid-Targeting Small-Molecule Inhibitor

The HIV-1 capsid plays multiple roles in infection and is an emerging therapeutic target. The small-molecule HIV-1 inhibitor PF-3450074 (PF74) blocks HIV-1 at an early postentry stage by binding the viral capsid and interfering with its function. Selection for resistance resulted in accumulation of...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Shi, Jiong, Zhou, Jing, Halambage, Upul D., Shah, Vaibhav B., Burse, Mallori J., Wu, Hua, Blair, Wade S., Butler, Scott L., Aiken, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301104/
https://ncbi.nlm.nih.gov/pubmed/25320302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01411-14
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