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Structure-Based Virtual Screening of the Nociceptin Receptor: Hybrid Docking and Shape-Based Approaches for Improved Hit Identification

[Image: see text] The antagonist-bound crystal structure of the nociceptin receptor (NOP), from the opioid receptor family, was recently reported along with those of the other opioid receptors bound to opioid antagonists. We recently reported the first homology model of the ‘active-state’ of the NOP...

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Autores principales: Daga, Pankaj R., Polgar, Willma E., Zaveri, Nurulain T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210177/
https://ncbi.nlm.nih.gov/pubmed/25148595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci500291a
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